KMID : 1101720160200020051
|
|
Physical Activity and Nutrition 2016 Volume.20 No. 2 p.51 ~ p.57
|
|
GLUT2 proteins and PPAR¥ã transcripts levels are increased in liver of ovariectomized rats: reversal effects of resistance training
|
|
Tomaz Luciane M.
Barbosa Marina R. Farahnak Zahra Lagoeiro Cristiani G. Magosso Natalia S.S Lavoie Jean Marc Perez Sergio E.A.
|
|
Abstract
|
|
|
[Purpose] This study investigated the effects of ovariectomy (Ovx) and 12 weeks of resistance training (RT) on gene expression of GLUT2, the main glucose transporter in the liver, and on PPAR¥ã, a transcription factor known to target GLUT2 expression.
[Methods] Forty Holtzman rats were divided into 5 groups: Sham-sedentary (Sed), Sham- RT, Ovx-Sed, Ovx-RT, and Ovx-Sed with hormone replacement (E2). The RT protocol consisted of sessions held every 72 h for 12 weeks, during which the animals performed 4 to 9 vertical climbs (1.1 m) at 2 min intervals with progressively heavier weights (30 g after the fourth climb) tied to the tail. The E2 silastic capsule was inserted into the rats¡¯ backs 48 hours before the first RT session.
[Results] In addition to liver fat, GLUT2 protein levels and PPAR¥ã transcripts were increased (P < 0.05) in Ovx compared to Sham-Sed animals, suggesting increased hepatic glucose uptake under estrogen deficient conditions. RT and E2 in Ovx rats decreased liver fat accumulation as well as GLUT2 and PPAR¥ã gene expression to the level of Sham- Sed animals.
[Conclusion] The results of this study suggest that liver GLUT2 as well as PPAR¥ã expression in Ovx rats are accompanied by increased fat accumulation and glucose uptake, thus providing a substrate for increased de novo lipogenesis. RT appears to be an appropriate exercise model to circumvent these effects.
|
|
KEYWORD
|
|
Liver fat, PEPCK, Hepatic glycogen, Exercise and Glucose
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|